ºÒȳªÆ®·ý ¹Ù´Ï½¬¿Í ¿ä¿ÀµåÈ Ä®·ýÀÌ Silver Diamine FluorideÀÇ Àç±¤È È¿°ú¿¡ ¹ÌÄ¡´Â ¿µÇâ
Effect of Sodium Fluoride Varnish and Potassium Iodide on Remineralization Efficacy of Silver Diamine Fluoride
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ÀÌ°ÇÈ£ ( Lee Kun-Ho ) - Dankook University College of Dentistry Department of Pediatric Dentistry
¾ÈÁØ¿ë ( Ahn Jun-Yong ) - Dankook University College of Dentistry Department of Biomaterials Science
±èÁ¾¼ö ( Kim Jong-Soo ) - Dankook University College of Dentistry Department of Pediatric Dentistry
Çѹ̶õ ( Han Mi-Ran ) - Dankook University College of Dentistry Department of Pediatric Dentistry
ÀÌÁØÇà ( Lee Joon-Haeng ) - Dankook University College of Dentistry Department of Pediatric Dentistry
½ÅÁö¼± ( Shin Ji-Sun ) - Dankook University College of Dentistry Department of Pediatric Dentistry
Abstract
ÀÌ ¿¬±¸ÀÇ ¸ñÀûÀº silver diamine fluoride(SDF)¸¦ µµÆ÷ÇÒ ¶§ ºÒȳªÆ®·ý(sodium fluoride, NaF) ¹Ù´Ï½¬¿Í ¿ä¿ÀµåÈ Ä®·ý(potassium iodide, KI)ÀÌ SDFÀÇ Àç±¤È È¿°ú¿¡ ¹ÌÄ¡´Â ¿µÇâÀ» À¯Ä¡ÀÇ ¹ý¶ûÁú Àΰø ¿ì½Ä º´¼Ò¿¡¼ ¹Ì¼¼°æµµÀÇ º¯È¸¦ ÅëÇØ ÃøÁ¤ÇÏ°í, µµÆ÷ Àü°ú ÈÄÀÇ Ç¥¸é ÇüŸ¦ ÁÖ»çÀüÀÚÇö¹Ì°æ(scanning electron microscopy, SEM)À» ÅëÇØ °üÂûÇÏ¿© ºñ±³ÇÏ´Â °ÍÀÌ´Ù.
¹ßÄ¡µÈ À¯±¸Ä¡ÀÇ ÀÎÁ¢¸é¿¡ ¹ý¶ûÁú Àΰø ¿ì½Äº´¼Ò¸¦ Çü¼ºÇÏ°í ºñÄ¿½º ¹Ì¼¼°æµµ¸¦ ÃøÁ¤ÇÑ ÈÄ, 4°³ÀÇ ±ºÀ¸·Î ³ª´©¾î I±º¿¡´Â SDF, II±º¿¡´Â SDF¿Í NaF ¹Ù´Ï½¬, III±º¿¡´Â SDF¿Í KI, ±×¸®°í IV±º¿¡´Â Áõ·ù¼ö¸¦ ó¸®ÇÏ¿´´Ù. 8ÀÏ °£ pH cyclingÀ» ½ÃÇàÇÑ ÈÄ ºñÄ¿½º ¹Ì¼¼°æµµ¸¦ ´Ù½Ã Çѹø ÃøÁ¤ÇÏ¿© ¹Ì¼¼°æµµÀÇ º¯È·®À» °è»êÇÏ¿´´Ù. ¶ÇÇÑ Ä¡¾Æ ¿¬¸¶ ÈÄ, Àΰø ¿ì½Ä À¯¹ß ÈÄ, ±×¸®°í pH cycling ÀÌÈÄ °¢ ±º¿¡ ´ëÇÏ¿© °¢°¢ 2°³ÀÇ ½ÃÆíÀ» ÀÌ¿ëÇÏ¿© SEM¸¦ ÃÔ¿µÇÏ¿© Ç¥¸éÀÇ ÇüŸ¦ °üÂûÇÏ¿´´Ù. ¿¬±¸°á°ú ¹Ì¼¼°æµµ´Â III±º¿¡¼ °¡Àå Å©°Ô Áõ°¡Çß´Ù. I±º°ú II±º ¸ðµÎ ¹Ì¼¼°æµµÀÇ Áõ°¡¸¦ º¸¿´À¸³ª µÎ ±º »çÀÌ¿¡´Â Åë°èÇÐÀûÀ¸·Î À¯ÀÇÇÑ Â÷ÀÌ°¡ ¾ø¾ú´Ù. IV±º¿¡¼µµ ¹Ì¼¼°æµµÀÇ Áõ°¡¸¦ º¸¿´À¸³ª ±× º¯È Á¤µµ´Â °¡Àå Àû°Ô ³ªÅ¸³µ´Ù. SEM °üÂû °á°ú I, II, III±ºÀÌ ¿ì½Ä À¯¹ß Á÷Èijª IV±º°ú ºñ±³ÇÏ¿© Ç¥¸éÀÌ ´õ ±ÕÀÏÇØÁö°í ºÒ±ÔÄ¢¼ºÀÌ °¨¼ÒµÈ ¾ç»óÀ» º¸¿´À¸¸ç, III±º¿¡¼ ¹«Á¤ÇüÀÇ ÇǸ· ÇüÅÂÀÇ Ä§ÂøÀÌ ³ªÅ¸³µ´Ù. ÀÌ·¯ÇÑ °á°ú¸¦ Á¾ÇÕÇØ º¸¸é SDF¸¸À» µµÆ÷ÇÑ ±º°ú SDF¿Í NaF, SDF¿Í KI¸¦ ÇÔ²² µµÆ÷ÇÑ °æ¿ì ¸ðµÎ Ç¥¸é ÇüÅ°¡ ±ÕÀÏÇØÁö°í ¹Ì¼¼°æµµ°¡ Áõ°¡ÇÏ¿´À¸¸ç ÀÌ¿Í °°Àº °á°ú¸¦ ±â¹ÝÀ¸·Î ±¸° ³»ÀÇ È¯°æ¿¡¼µµ Àç±¤È È¿°ú¸¦ °¡Áú ¼ö ÀÖÀ» °ÍÀ¸·Î »ç·áµÇ¾ú´Ù. ¶ÇÇÑ ÀÌ ¿¬±¸ÀÇ Á¦ÇÑµÈ Á¶°Ç ÇÏ¿¡¼ NaF ¹Ù´Ï½¬¸¦ »ç¿ëÇÏ¿´À» ¶§¿¡´Â SDFÀÇ Àç±¤È È¿°ú¸¦ Áõ°¡½ÃÅ°Áö ¸øÇßÀ¸¸ç, SDF¿Í KI¸¦ ÇÔ²² µµÆ÷ÇÑ °æ¿ì SDFÀÇ À籤Ȱ¡ È¿°ú°¡ Áõ°¡µÇ´Â °á°ú¸¦ º¸¿´À¸³ª ÃßÈÄ ½ÇÁ¦ ±¸° ³»¿¡¼ÀÇ ´Ù¾çÇÑ »óȲÀ» °í·ÁÇÑ Ãß°¡ÀûÀÎ ¿¬±¸°¡ ÇÊ¿äÇÒ °ÍÀ¸·Î »ý°¢µÈ´Ù.
The purpose of this study was to compare the effect of sodium fluoride(NaF) varnish and potassium iodide(KI) on remineralization efficacy of silver diamine fluoride(SDF) by measuring microhardness and evaluating surface morphology by scanning electron microscope(SEM). Artificial caries lesions were induced on extracted primary molars and vickers microhardness was measured. Specimens were randomly separated into 4 groups for treatment. The specimens in group I were treated with SDF, group II with NaF varnish after SDF, group III with KI after SDF and group IV with distilled water. After 8 days of pH cycling, vickers microhardness was measured and difference before and after treatment was calculated. For SEM, 2 samples were evaluated respectively after enamel polishing, lesion formation and after pH cycling. Group III showed highest increase in microhardness. Group I showed higher increase in microhardness than Group II but without statistical difference. Group IV showed lowest increase in microhardness value among 4 groups. On SEM image, group I, II and III showed smoother and less irregular surface compared to group IV. Amorphous crystal pellicles were observed in group III. In conclusion, SDF, SDF and NaF, SDF and KI groups showed smoother surface and increase in microhardness suggesting the possibility that remineralization effect might take place in oral conditions. In addition, in limited conditions of this study, applying NaF varnish after SDF did not increase the remineralization efficacy of SDF while KI significantly increased the remineralization efficacy of SDF. However, additional study considering various conditions that might affect demineralization and remineralization in clinical situations need to be conducted.
Å°¿öµå
Silver diamine fluoride; Sodium fluoride varnish; Potassium iodide; Remineralization; Microhardness; Artificial caries
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